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Additional models: cartilage, endocrine, kidney In cartilage/chondrocyte culture models: FOXO4-DRI reduced the number of senescent chondrocytes significantly, while healthy chondrocytes remained intact

However, MLKL was not involved in triclosan-induced cell death of erythrocytes, probably excluding necroptosis as a cause of death [208], since the NCCD defines necroptosis as an MLKL-dependent RCD [6]