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Some individuals, particularly those with severe obesity or conditions such as type 2 diabetes, chronic kidney disease or heart disease, may benefit from longer-term treatment

GLP-1 weight-loss drugs such as Wegovy and Zepbound have taken the health care world by storm, with hundreds of thousands of people turning to the medications for their pound-shedding properties

For high variability drugs, scaled average bioequivalence for Cmax may be used

A systematic review describes oral semaglutide with a weight reduction of approximately 10 to 12 percent, which corresponds to roughly two-thirds of the effect of the subcutaneous variant at optimal dosing (Cureus, 2025)

Kremers, B