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Although laboratory studies suggest a potential role in alleviating diabetes, the development and translation of HDAC inhibitors for diabetes therapy are still in the early stages, highlighting the importance of future research in unraveling their mechanisms, optimizing drug delivery processes, and evaluating long-term safety through clinical trials to assess their efficacy in combating T2DM effectively

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In fact, incorporation of brachytherapy remains one of the most robust independent predictors of long-term survival, with reported local control rates exceeding 8090% in many series when combined with concurrent chemoradiation [92, 93]