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In chronic weight management, GLP-1 medications are sometimes used in conjunction with a low-calorie diet and increased physical activity
[1] There is a theoretical concern regarding serotonin syndrome, though there is no established direct pharmacological mechanism for this interaction
Hypothalamic POMC neurons promote cannabinoid-induced feeding
The current medical consensus, supported by the EMA's 2013 review and subsequent updates, is that whilst a small increased risk cannot be entirely excluded, the overall evidence does not establish a definitive causal link between GLP-1 agonist use and pancreatitis