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According to some studies it has been found that it is most often transmitted from uncle (mother's side)
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10.1002/aur.70 146
Notably, addition of hemin or pyruvate, a source for NAD+ did not impact these growth phenotypes, suggesting that amelioration of heme defect or respiration inhibition is not sufficient to overcome anti-proliferative effects of mitochondrial GSH depletion (Extended Data Fig
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