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The absence of these endpoints limits the ability to determine whether observed changes in lean mass translate into clinically meaningful impairments

Fivelman Q, Adagu I, Warhurst D (2004) Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum

In further asepcts, the invention provides methods of reversing, ameliorating or slowing progression of at least one symptom of Lewy body pathology in a patient in need thereof

Evidence suggests that age-related melatonin decline contributes to accelerated aging through increased oxidative stress, mitochondrial dysfunction, and inflammatory burden (inflammaging), whereas restoring melatonin levels, via supplementation or diet, may mitigate such processes