Repeat-dose study in diabetic db/db mice Male db/db (BKS.Cg-m+/+Leprdb/J) mice (Charles River
For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]
Initially developed for T2DM, these drugs have proven to be highly effective in reducing body weight and improving metabolic health in adolescents with obesity
Probiotics Role in the Body : Probiotics are beneficial bacteria that promote gut health, aiding in digestion and nutrient absorption
There is a unique opportunity for collaboration across specialties to raise awareness around the multiple benefits of GLP-1 RAs and determine the best care pathway to treat patients with PAD. With the ongoing PAD amputation and obesity epidemics, there is an opportunity to establish partnership and open communication between vascular surgeons and weight loss clinics to determine if a patient could benefit from GLP-1 RAs
