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For moderate bioavailability, the recommended intake increases to 7.0 mg per day for men and 4.9 mg per day for women

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Additionally, Sermorelin's effects decline when pituitary capacity is exhausted or inhibitory signals (somatostatin) are active, providing intrinsic safety compared to pharmacological GH administration

Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma

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