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3.3 The role of stress and mental health Chronic stress and mental health disorders such as depression, cognitive impairment, psychological distress, and anxiety have been increasingly implicated in the progression and worsening of CKD, with the gut-brain axis playing a central role in this connection (Gela et al., 2024)

Unlike water-soluble antioxidants that require constant replenishment, ergothioneine functions as a strategic cellular reserve

Because DMSO serves not only as a vehicle for various hydrophobic compounds but also as a cryoprotectant for cell storage, most researchers and engineers in life sciences (hundreds of thousands to millions of people) use DMSO and it has been recognised as an irreplaceable solvent 3,4,5,6,7

Availability of data and materials The data that support the findings are available from the Exercise and Biochemical Nutritional Laboratory (EBNL) in the Department of Human Performance of Baylor University and the grant sponsor, being the Function Research Group of Kyowa Hakko Bio Co., Ltd

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