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4 weeks Minimum interval between dose increases 2mg to 12mg Phase 2 dose range (Jastreboff 2023) ~12 weeks Time to reach 12mg on standard protocol 24.2% Weight loss at 12mg, 48 weeks (Phase 2) Investigational Drug Warning Retatrutide (LY3437943) is not FDA-approved as of April 2026

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For longevity protocols or recovery from a hard stretch, many clients start with a series of 4 sessions over 2 to 4 weeks, then move to monthly maintenance