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Cardiovascular outcome studies of GLP-1R agonists do not affect the rate of heart failure hospitalization, while decreasing the rate of myocardial infarction and stroke [3,4,5]

Furthermore, access to GLP1-RAs is a major issue for uptake remaining relatively low despite the high efficacy of these medications (Rodriguez et al., 2025)

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Viking Therapeutics' VK-2735 dual GLP-1/GIP agonist demonstrated weight loss of up to 14.7% after just 13 weeks in early trials, generating significant investor interest [45]

A question arises: Can the clearance of apixaban by intestinal excretion (ClI) be added to its clearance in the liver and kidney (CLR and CLH, respectively)