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doi: 10.1038/oby.2004.76 99 HollanderPALevyPFinemanMSMaggsDGShenLZStrobelSAet al

The current evidence suggests that: Dose-dependent efficacy : Both glycaemic and weight outcomes improve with increasing doses within the therapeutic range, suggesting that very low doses are unlikely to provide substantial benefit

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Gut dysbiosis can lead to higher concentrations of these hormones, which can inhibit hormone signaling and alter energy metabolism ( N Engl J Med , 2024)