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In summary, lipid metabolism orchestrates Th17/Treg balance through multiple interconnected mechanisms: extracellular lipids provide environment-dependent signals, endogenous synthesis and oxidation pathways fuel functionally distinct metabolic states

Several dipeptidases appear to perform this reaction in the extracellular space, and carnosine dipeptidase (CNDP) 2 has been identified as a protein that preferentially reacts on the Cys-Gly dipeptide in yeast [129]

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so the brain is protected from Se deficiency (Zhang et al., 2008)