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mayoclinic.org (trusted non-journal) Cleveland Clinic

(Endocrine Reviews, 1991) documented that combined GHRH + GHS-R agonist administration produces GH release 2-5 fold greater than either compound alone, providing the scientific rationale for the CJC-1295 ipamorelin blend approach

It is chemically very similar to the body's own natural growth hormone-releasing peptide (GHRP)-1, with the main difference being that it lacks the central dipeptide Ala-Trp found in GHRP-1 [11]

Zhang X, Xia B, Zheng H, Ning J, Zhu Y, Shao X, Liu B, Dong B, Gao H

The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis