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Key Takeaways Although a lot of data exists about using GLP-1 medications to treat diabetes, there isnt as much data yet supporting their long-term use for obesity

Multiple studies, usually done during endoscopies (EGDs) with or without colonoscopies, have shown that patients on GLP-1 receptor agonists have residual gastric contents when fasting from solids for 8 hours (70% of patients, n=10) and when fasting from solids for up to 16 hours (13.1% after 10 hr, n=84

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However, under oxidative stress conditions, Nrf2 dissociates from Keap1, accumulates in the cytoplasm, and is transported into the nucleus to bind to target genes