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Loading phase uses higher doses (2.5-5mg) 2x weekly for 4-6 weeks to rapidly saturate tissues and initiate healing

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Studies with a pragmatic design, high discontinuation rates, or shorter study durations could have limited overall exposure to the study GLP-1 RA, which ultimately could have dampened the ability to detect a difference if one existed

Similarly, a significant difference in BMI was observed across nicotine craving categories

Patients often start with an intensive "loading phase," which can mean daily or every-other-day injections for a week, then weekly shots for a month