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With the development of next-generation sequencing technologies such as 16S rRNA gene sequencing, internal transcribed spacer region (ITS) sequencing, Polymerase Chain Reaction (PCR), Birdshot Macro-genomics, Macro-transcriptomics, Metabolomics, and Macro-proteomics Mass Spectrometry, etc., the study of esophageal microecology has been gradually improved (11)

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These conditions might facilitate continual re-stimulation of GLP-1R to maintain the ongoing insulin release, as suggested by the trajectory of insulin accumulation in Fig

The drug semaglutide GLP-1 induces the release of glucagon-like peptide-1 (GLP-1)

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