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Pegaptanib sodium (Macugen) has limited efficacy in the treatment of DME because it selectively inhibits only the VEGF 165 isoform, without targeting the three other pathological isoformsVEGF 121 , VEGF 189 , and VEGF 206 [98]

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It is possible that BPC 157 may affect voltage-gated sodium channels (VGSCs), which play a major role in the generation and propagation of action potentials in primary afferents [67]

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NRIs clinical trials incorporate meticulous monitoring protocols, dose-optimization strategies, and individualized risk assessments to ensure that participants receive maximal benefit with minimal adverse effects