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GLP-1 weight-loss drug use surges across Australia amid safety warnings and supply shortages, NewsWire

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Descriptions summarise published, PubMed-indexed laboratory findings and refer to research contexts only

The first animal studies showing that GLP-1 potentially had effects on the CV system was published in 2002, and the first study to show cardioprotection was in 2008 (102, 211), but it was not until the LEADER cardiovascular outcomes trial (CVOT) with liraglutide, published in 2016, that a reduction in CV risk with a GLP-1RA was documented (100)