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Individual metabolic response, adherence, and lifestyle factors play a larger role in real-world outcomes than trial averages suggest

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Spironolactone (brand names: Aldactone and CaroSpir) is a potassium-sparing diuretic (water pill) approved by the Food and Drug Administration (FDA) to treat congestive heart failure, high blood pressure (hypertension), edema (fluid retention) associated with liver cirrhosis or certain kidney problems, and hyperaldosteronism, which is an excess of the hormone aldosterone that can cause high blood pressure

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