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Medical experts warn that caution should be exercised when considering the coadministration of budesonide suspension inhalation with ketoconazole and other known strong CYP3A4 inhibitors because adverse effects related to increased systemic exposure to budesonide may occur

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As the protocol progresses, the dose may be increased to 15 units by Week 3 and then advanced to 22.5 units by Week 5 , provided the blend is well tolerated within the context of the educational model

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To study vaspin effects on cellular signaling and metabolism, 500 ng/ml of recombinant human vaspin was added to cells for 5-20 min prior stimulation, except when using primary brown adipocytes from VasTg mice