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During the silent motor period, from a clinical point of view, there are no observable motor symptoms

doi:10.1053/j.gastro.2016.02.017 Retrieved from Hurtado, M.D., Tama, E., Fansa, S., et al

Image credit: However, a small study conducted healthy Thai male volunteers has found out that coffee enema does not raise the level of glutathione S-transferase in the volunteers blood

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Besides its use as BBB permeability and transport screen, the model has also been used in mechanistic studies in physiological and pathological conditions