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Together, the combined activity of KLOW80 allows researchers to study coordinated angiogenic signaling, extracellular matrix remodeling, and cellular migration in preclinical tissue repair models
These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue
Lentz SR
