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For example, in the lungs, GLP-1s may reduce the inflammatory response, improve oxidative stress, regulate protease/anti-protease imbalance, improve airway mucus homeostasis, and reduce airway remodeling to provide benefit in patients with COPD

We inhibited the function of the p53 negative regulator human double minute 2 (HDM2) using the potent and specific small molecule inhibitors nutlin-3 and MI-773/SAR405838 (Vassilev et al, 2004

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