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The strategy for the management of type 2 diabetes was updated in 2018 in response to the abundance of new cardiovascular outcome data from the CVOTs published since 2015, which showed safety, tolerability, and cardiovascular and renoprotection with 2 classes of agents, sodium glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide receptor agonists (GLP1RA) in patients with established CVD (11)

In healthy men, intraduodenal infusion of glucose induces a rapid 200% increase in GLP-1 that returns to baseline by 30 min (Herrmann et al., 1995)

Algunos pacientes tambin suspenden prematuramente el tratamiento debido a efectos secundarios gastrointestinales como nuseas, vmitos o diarrea, que suelen ser transitorios y disminuyen con el tiempo

Frontiers in Endocrinology, 14, 1209975

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