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Lack of randomized controlled trials: No large-scale human RCTs testing peptides for bone or cartilage healing published in major medical journals

Takeaway: GHK-Cu is the most compelling "signaling" peptide for skin strong mechanism, long cosmetic track record, but a thinner modern RCT base than oral collagen

Additionally, a co-culture system of MCECs and MPMs revealed that GHK-Cu facilitated MCECs healing, impaired by DSS, by upregulating ZO-1 and Occludin expression

Subtle daily exposuresplastics, chemicals, endocrine disruptorscan add up

STING can induce autophagy independent of TBK1 and IRF3 via an LR motif at the C-terminus of STING (141, 157)