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CHCHD2, a mitochondrial stress response protein, is involved in OXPHOS and the maintenance of cristae morphology [103]

Current strategies focus not only on targeting the BBB endothelium but also on the effective transport of specific compounds across it and the subsequent targeted drug release at appropriate targets in the brain ( Strategies under study to cross the BBB include viral vectors (257) as gene therapy delivery, enhancement of brain permeability (258), delivery through the pathologic permeable BBB, intranasal drug administration to bypass the BBB (259), nanoparticles (NPs) to actively target the brain, or delivery through active BBB transporters (260), brain cancer (261), and even stroke (262)

doi: 10.1139/y2012-090

Biogerontology 14, 303323

Liposomal Technology & Delivery Science Phospholipid Architecture 82.05% Phosphatidylcholine (PC) and 10.82% Phosphatidylethanolamine (PE), yielding 93% phospholipids