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However, LCACs promote the formation of a tetrodotoxin (TTX)-sensitive late Na + current (I Na(L ) ) that exhibits a markedly prolonged channel inactivation period and drives an increase in intracellular Na + concentration (Wu and Corr, 1994)

The catalytic glutamate residue E 115 accepts a proton from the -glutamyl group of the substrate, initiating a nucleophilic attack by the amine on the amide carbon atom

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