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Phase Maximum dose Weeks 17-20+ Weekly Dose 12 mg Notes Highest dose studied

aeruginosa gshA, gshB and gshAgshB double mutants defective in GSH synthesis were attenuated in a mouse model of acute pneumonia [27] yet the gshA mutant was equally virulent as the wildtype in surgical wound, abscess and acute burn wound murine infection models [28]

Most of those mitochondria will have identical DNA called homoplasmy

215,216,217 IRE1 induces XBP1 splicing, resulting in spliced XBP1 (XBP1s), which regulates the expression of chaperones, including ERdj3, ERdj4, EDEM, PDI, and ribosome-associated membrane protein 4 (RAMP-4)

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