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While skin color is determined by genetic makeup, slight, timely modifications of skin tone are being made through sun exposure, aging, or hormonal changes

In a randomized controlled trial, 71 patients were pretreated with intravenous amifostine before platinum/taxane-based chemotherapy for ovarian cancer in order to determine whether such premedication changed the incidence of neurotoxic side effects

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Additionally, it has been shown that cytokines can trigger OS and neurotoxicity by activating macrophages in brain tissue, leading to the release of IM [147]