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The role of the ubiquitin proteasome system (UPS) in the heart The UPS as a central and highly selective proteostasis system in cardiomyocytes Alongside autophagy and mitophagy, the ubiquitinproteasome system (UPS) represents a central pillar of cardiac proteostasis, responsible for the highly selective degradation of damaged, misfolded, or regulatory proteins and thereby safeguarding cellular homeostasis and protein turnover (Fig

1+1+1+1=4, not 5

Khaldi N, Seifuddin FT, Turner G et al (2010) SMURF: Genomic mapping of fungal secondary metabolite clusters

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