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Safety and side effects Both forms can cause nausea, vomiting, diarrhea, constipation, bloating, and reduced appetite, especially early in treatment or after dose increases such as moving up from Rybelsus 3 mg [1]

The STEP trials demonstrated that semaglutide produces sustained weight loss of 15-22% of initial body weight over 68 weeks, significantly exceeding results from traditional non-GLP-1 medications

Abbreviations ARNI, angiotensin receptor neprylisin inhibitor

Potential side effects include temporary swelling, bruising, pain, and numbness

GLP-1 derivative liraglutide in rats with -cell deficiencies: influence of metabolic state on -cell mass dynamics