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There has been controversy about the incidence of melanoma and thus the clinical management of CMN, which is partly due to the difficulties of histological diagnosis and partly due to publishing bias towards cases of malignancy

Nat Rev Gastroenterol Hepatol 9 , 705715 (2012)

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Stelara: Stelara is blockbuster drug of Johnson and Johnson which is expected to lose its patent in 2026

Less Common or Serious Side Effects In rare cases, patients may experience more significant side effects that require immediate medical attention, such as: Severe abdominal pain Signs of allergic reaction (swelling, rash, difficulty breathing) Persistent vomiting Symptoms of low blood sugar (shakiness, sweating, dizziness) If any of these occur, patients are advised to stop the medication and contact their provider right away