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En cualquier diseo preclnico se requiere consentimiento institucional y monitorizacin de peso, ingesta calrica y signos clnicos durante la fase de titulacin

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[76] Ruminants, such as cows and sheep, are foregut fermenters, meaning that plant food undergoes microbial fermentation in the rumen before entering the true stomach (abomasum), thus allowing them to absorb the vitamin B 12 produced by the bacteria