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In the context of GLP-1R agonists, GLP-1-expressing NTS neurons project to the VTA [98], and administration of exendin-4 into this brain region reduces food intake [98,99,100] and the motivation to obtain a food reward [99, 100] without causing aversion [98,99,100]

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This effect was observed in brain slices from Pomc-EGFP mice after stimulation with GLP-1(7-36)amide, that dose-dependently depolarizes POMC-neurons and increases the frequency of action potentials [195]