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Common episode features include: Elevated or irritable mood during mania/hypomania Decreased need for sleep without fatigue Increased goal-directed activity or impulsive decisions Depressive episodes with low energy and loss of interest Impaired judgment during elevated states Key Symptoms and Patterns in Bipolar Disorder Bipolar disorder shows up as clearly defined episodes, not moment-to-moment shifts

PDE5 inhibitors are contraindicated in patients taking nitrates for angina and the medication riociguat

For best results, injections are given intramuscularly in areas such as: Patients may receive injections in-office or learn safe self-administration at home

To manage pain, avoid hard foods and use ice packs

Possible interactions include: Colchicines Heavy alcohol intake This list may not describe all possible interactions