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Conversely, in uterine fibroids, it induces a pro-oxidative state characterized by elevated intracellular ROS levels, thereby promoting fibroblast apoptosis and reducing glycolysis and fibrosis

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INCRELEX should not be used by patients who are allergic to mecasermin (rhIGF-1) or any of the inactive ingredients in INCRELEX, or who have experienced a severe hypersensitivity to INCRELEX [see Warnings and Precautions (5.2) and Adverse Reactions (6)]