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doi: 10.1111/j.1600-079X.2004.00181.x 223 Bezerra EspinolaMSBilottaGAragonaC

Excess food intake or rapid gastric emptying that exceeds the absorptive capacity of the upper small intestine increases the amount of unabsorbed nutrients in the lumen of the more distally located small intestine, thereby increasing the amount of GLP-1 secretion

(122) had previously demonstrated presynaptic effects of PregS

Zhong G, Wan F, Ning Z, Wu S, Jiang X, Tang Z, et al

In 1967, Perley and Kipnis conducted a further study in which they showed that the insulin produced during the incretin effect in humans accounted for more than half of the total insulin secreted by oral glucose ingestion (Perley and Kipnis, 1967)