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By blocking DHFR, methotrexate interferes with DNA replication and increases oxidative stress

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Alcohol use disorder (AUD) is a chronic, relapsing brain disorder

Every 1-6 months, the investigators monitored body weight, heart failure symptoms, major worsening heart failure events, changes in heart failure medications and adverse events

Initially, semaglutide treatment begins with the lowest effective dose, incrementally adjusted as your body responds