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The researchers confirmed that both patient cohorts exhibit profound signs of elevated oxidative stress, particularly in memory T-cells, alongside severe decreases in mitochondrial superoxide dismutase protein levels and elevated lipid oxidative damage

In the Phase 2 clinical trial published in The New England Journal of Medicine in 2023, gastrointestinal side effects affected the majority of participants, with nausea, vomiting, diarrhea, and constipation being the most frequent complaints

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Contact your healthcare provider for evaluation of alternative causes such as hypoglycemia, infections, hormonal changes, or other medications

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