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Together these data indicate that although vagal afferent neurons may contribute to hypophagia induced by peripheral administration of GLP-1R analogs, these neurons are not necessary for the hypophagic effect

That absence of abdominal pain is the single element that separates functional diarrhea coding (K59.1) from IBS-D coding (K58.0)

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Initial results from retatrutides first phase 3 trial showed an average weight loss of 28.7% at 68 weeks on the highest dose We will also undoubtedly see patent thickets being employed by filing multiple secondary patents directed to methods of manufacture, formulations, patient groups, dosage regimens and related indications to extend market exclusivity beyond the core compound patents