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No unexpected safety issues have arisen to date, and the established safety profile for semaglutide is similar to that of other GLP-1RAs where definitive conclusions for pancreatic and thyroid cancer cannot be drawn at this point due to low incidence of these conditions.4 Conclusion Semaglutide has shown significant weight reduction of up to 20%, as well as other significant health benefits seen in cardiovascular disease, stroke, and kidney function in clinical trials over long term use