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Additionally, the utilization of UDE containing 1000 M -EC resulted in a negative impact on cell viability, whereas treatment with 1000 M -EC alone did not exhibit any toxic effects

Nanoparticles responsive to GSH are capable of delivering both chemotherapeutic drugs and inhibitors, such as an oxaliplatin-based prodrug combined with an IDO-1 inhibitor (indoleamine 2,3-dioxygenase 1)

These improvements are likely by activating the Peroxisome proliferator-activated receptor (PPAR), enhancing glycolysis, inhibiting gluconeogenesis, and upregulating the expression of GLUT2, GLUT3 and GLUT4 genes 28

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