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Waist circumference improvements were also greater with the higher dose, with an average additional reduction of nearly 12 cm or 4.72 inches compared to placebo

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By week 20, eGFR levels were similar between the semaglutide and placebo groups

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Findings from the preclinical study confirmed that miR-212-3p has a neuroprotective effect against the pathogenesis of AD by inhibiting the expression of NLRP3 inflammasome, attenuating the expression of -secretase and reducing neuronal pyroptosis in AD rat model (Nong et al