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NSAIDs (ibuprofen-like drugs), acetaminophen, membrane-stabilizing drugs, muscle relaxants, and other analgesics are often used in the management of pain associated with sciatica

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Although there are evidenced-based data supporting certain treatment approaches for patients in clinical studies, the unsolved question in clinical practice remains: "Who is the ideal patient for a given treatment approach?" Thus, treatment of IC/BPS often requires a trial-and-error approach