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Downstream, an independent 2021 study in APP/PS1 mice linked the memory effect to PI3K/AKT signaling, blocked by the inhibitor wortmannin [3] coherent, but still a mouse result

Published research has quantified this effect directly: at concentrations of 12 M, only 1020% of expected peptide content was recovered from standard borosilicate glass vials and polypropylene tubes after incubation, while low-binding tubes showed significantly better recovery

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