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In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis

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With a half-life of 48 h, its life is around 10 days

4 TABLE 1 summarizes typical dosing for adults and adjustments for renal disease

A double-blind randomized controlled trial showed that treatment with the anti-RANKL antibody, denosumab, significantly inhibited the progression of joint destruction and was well tolerated, which is expected to become the clinical treatment for RA (283)