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96% of patients achieved more than 5% fat mass loss compared to 21% on diet and exercise counselling alone
Collectively, these studies highlight the potential role of endocrine and central (hypothalamic) dysfunction in the altered homeostatic metabolic status in AN, as described in animal models (Boghi et al., Figure 2 At the hypothalamic level, ghrelin has also been reported to act directly or indirectly on other nuclei linked to feeding control such as the VMH, PVN, and LHA (Lpez et al., 2008
p = 0.0228), were found
This was a landmark moment because it represented global recognition of GLP-1 medications as a legitimate long-term treatment for obesity rather than a temporary or supplementary intervention
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