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Stomach acid and various digestive enzymes in the gastrointestinal tract may degrade glutathione, resulting in its lower bioavailability

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Finally, given the minimal de novo generation of OLGs from OPCs in the brains of adult humans, including MS patients (Yeung et al., 2014, 2019), efforts should also be made to identify factors capable of boosting mature OLG survival and plasticity during acute demyelination