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A systematic review and meta-analysis published in the Journal of Hepatology found that while metformin may improve aminotransferase levels and insulin resistance markers, it does not consistently reduce liver fat content or improve histological features of MASH

Editors Note: Following a May 2026 global consensus, polycystic ovary syndrome (PCOS) is now officially called polyendocrine metabolic ovarian syndrome (PMOS), highlighting the metabolic roots of the condition

For individuals prescribed GLP-1 receptor agonists as part of a comprehensive diabetes or obesity management plan, incorporating allulose as a sugar substitute could support treatment goals without compromising palatability

In some embodiments, the otic formulation or composition comprises about 0.6% by weight of the cholesterol